Development of downstream processing is a critical step as it significantly affects the reproducibility, scalability and economically of your commercial process. Okmed Biotech can develop robust, effective and optimized procedures for purification of therapeutic proteins directly from microbial cell cultures.


Our services target to establish a process delivering the desired purity and quality attributes, while providing process robustness, reproducibility and scalability. Our team can provide support for:


• Optimization of the harvest conditions for cells

• Development of the extraction conditions (high pressure homogenization, chemical lysis)

• Preparation, solubilization and refolding of inclusion bodies

• Selection of chromatography conditions and resin

• Filtration conditions (membranes and screening of process conditions)

• Scaling-up studies



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Weinbergweg 23 06120 Halle (Saale) Germany